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Trauma

Our Centre for Trauma Sciences is a world-leading Centre of excellence for translational research. Working alongside the Major Trauma Centre at the Royal London Hospital, we support the work of Barts Health NHS Trust as it delivers its care in acute medical specialties including Trauma, Intensive Care, Emergency Medicine and Perioperative Medicine.

Our trauma research themes include many aspects of the acute response to tissue injury in surgical patients, the critically ill, and victims of major trauma. We are also exploring long-term effects of acute illness including post trauma reconstruction, recovery from acute kidney injury and major surgery.

Current funds in our Trauma research total more than £13m from NIHR, MRC, EU FP7, Wellcome Trust, Barts Charity and industry, and our vision is to make Barts and The London the place to train in trauma sciences and acute care.

Testing whether cryoprecipitate saves lives

£2.4m was awarded by the NIHR and Barts Charity to carry out a large multi-centre Randomised Controlled Trial to evaluate early cryoprecipitate in major traumatic haemorrhage (CRYOSTAT-2). The trial will test the effect of early cryoprecipitate (within 90 minutes of admission) compared to standard blood transfusion therapy on 1,544 severely bleeding trauma patients, at all Major Trauma Centres (MTCs) across England and selected international partners in North America and Australia.

Artesunate for Trauma

Supported by a Health Innovation Challenge Fund from the Wellcome Trust and the Department of Health, a phaseII placebo control trial will investigate the effects of the antimalarial drug, artenusate in over 100 traumatic patients with severe hemorrage (code red). Of interest, this trial spawns from discovery science work.

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