Exercises in genetic linkage analysis - conditions of use

All the material in these pages, including the example data files provided for these exercises (but not including the programs required or example files distributed with them), and including the essential structure of the exercises and the organisation of the relevant files is copyright (C) Dave Curtis, 1996-2000. While retaining this copyright, I am distributing this material under the conditions listed below.

Essentially, the exercises are free for personal use or for use by non-profit health and educational institutions except for very large genome centres or for when they are used as part of a teaching course. They are not really designed for personal use - if you are competent to set up all the necessary programs then you probably won't get all that much out of the exercises. Rather, they are designed either to be set up as a resource for institutions carrying out genetic analyses so that researchers wishing to gain some basic familiarity with the practicalities of linkage analysis can be directed to the exercises and advised to work through them, hopefully with minimal supervision, or else they may be used as the basis for a taught course.

If the exercises are used as part of a taught course then royalties are payable. A taught course is defined as a course in which three or more students work through the exercises simultaneously, with some kind of supervision or help from an instructor. Royalties are payable whether or not the students specifically pay to work through the exercises. It might be the case, for example, that a group of PhD students were taken through the exercises as part of a much larger course in genetics or molecular biology. Alternatively, one could set up the exercises and use them as the substantive basis for an introductory course in linkage analysis for which one might charge students a substantial tuition fee. In either case royalties would be payable for the use of the exercises.

It is intended that use should be free for moderately-sized non-profit health and education institutions and for those centres not particularly specialising in genetic research. However royalties are payable by for-profit institutions and by large genome centres. Thus usage will be free for a medical school in which only a few research groups are performing linkage analyses, each group only having two or three members involved in the computational work. However large genome centres providing computing resources and/or training to significant numbers of individuals and which may attract a large number of users for the exercises will need to pay royalties. Non-profit institutions expecting no more than 30 users per year to work through the exercises need pay nothing. Larger institutions and for-profit institutions must pay royalties, and this partially relates to the expectation that such institutions may require customised installations and enhanced user support. (Note that the 30-users-per-year limit applies to the number of users realistically expected to make use of the exercises, not to the perhaps much larger number of users who may hold an account on the system and be potentially able to access the exercises.)

Conditions of use

Royalties

Royalties are payable by institutions expected to have a large number of users of the exercises, by for-profit institutions and whenever the exercises are used as part of a taught course. In every case when royalties are payable, a specific agreement must be negotiated and agreed in advance. This will take account of particular circumstances, including factors such as the amount of support and customisation expected, and whether only some of the exercises are to be used. The sums mentioned below are for guidance only.

Royalties for taught courses

When these exercises are used for a taught course (i.e whenever three or more people are taken through the exercises simultaneously) a fee is payable. As a rough guide, the expected fee will be 20 UKP (30 US $) per student on the course. I hope that this figure will be regarded as reasonable, given that the exercises provide enough practical material for a 2 or 3 day course (depending on the expertise of the students and the amount of additional theoretical material included) and that tuition fees for such a course might therefore range from 300-600 UKP (500-900 US $) per student depending on the quality of tuition and other factors. The royalties are payable even if no such charge is made explicitly for the course which the exercises form a part of.

Royalties for non-exempt institutions

For-profit institutions and those expecting an exceptionally large number of users to work through the exercises (above 30 per year) are obliged to pay royalties, again to be negotiated in advance and to be dependent on exact circumstances. As a rough guide, for non-profit health or educational institutions a figure of 2 UKP (3 US $) per expected user per year will be payable, whereas for-profit institutions will pay twice this rate.

Support

I am keen to make these exercises as widely available as possible, and I would be very glad to hear of any problems involved and suggestions for improvements. Without making a specific commitment, I would hope to be able to support people in making these exercises available on their local systems, and in ensuring that they run as smoothly as possible. Please don't hesitate to contact me and I will do what I can to help.

Exercises in genetic linkage analysis

All material copyright (C) Dave Curtis 1996-2000

dcurtis@hgmp.mrc.ac.uk