Neuroleptic malignant syndrome (2)
NMS is due to disturbance of dopamine transmission
- Occurs with all anti-dopaminergic agents (anti-emetics as well as anti-psychotics)
- Can occur with withdrawal of dopaminergic drugs used to treat Parkinson's disease
- Occurs with atypical antipsychotics, including clozapine, although presentation may be less typical
In NMS pyrexia is due to:
- Muscular contraction occurring as an extrapyramidal side effect
- Central disturbance of temperature control
nms1.html
nms3.html