Pharmacogenetics - Power to detect effects
What is the likely magnitude of interactive effects between genotype
and drug response?
What kind of methods are likely to establish these effects when issues of multiple testing are considered?
- Association studies with candidate genes - need Bonferroni correction for number of polymorphisms studied
- Genome scans using linkage - need to achieve p<0.0001
- Genome scans using association - with 1000 SNPs need to achieve p<0.00001
- However 1000 SNPs yield about 100,000 short haplotypes - need to achieve p<0.0000001